Journal of Nature Communications – Figure 7

On The Cover: Environmental and genetic interaction converges on the Golgi N-glycan branching enzyme Mgat1 and N-glycosylation of CTLA-4 in T cell blasts. Both down- or upregulation of Mgat1 activity decrease branching by limiting N-glycan or UDP-GlcNAc substrate to...

Journal of Immunological Reviews – Figure 2

Figure. 2 – Regulation of basal TCR signaling by the galectin-glycoprotein lattice. Galectin binding to N-glycans attached to the TCR complex (which is depicted as a single ribbon) inhibits basal signaling via Lck by actively blocking spontaneous TCR oligomerization...

Journal of Immunological Reviews – Figure 5

Figure. 5 – Metabolism controls cell growth by regulating the galectin-glycoprotein lattice. The nutrient environment and/or growth signaling by TCR influences UDP-GlcNAc production by the hexosamine pathway, which in turn regulates N-glycan branching in the Golgi to...

Journal of Immunological Reviews – Figure 4

Figure. 4 – Regulation of CTLA-4 mediated growth arrest by the galectin-glycoprotein lattice. Galectin binding to N-glycans attached to CTLA-4 enhances surface retention by opposing endocytic loss, resulting in sustained and increased arrest signaling. CTLA-4...

Journal of Immunological Reviews – Figure 3

Figure. 3 – Regulation of T cell activation thresholds by the galectin-glycoprotein lattice Galectin binding to N-glycans attached to the TCR complex (which is depicted as a single ribbon) restricts clustering of TCR at the immune synapse in response to agonist...

Pin It on Pinterest