Journal of Immunological Reviews – Figure 3

Figure. 3Regulation of T cell activation thresholds by the galectin-glycoprotein lattice
Galectin binding to N-glycans attached to the TCR complex (which is depicted as a single ribbon) restricts clustering of TCR at the immune synapse in response to agonist (LEFT). Peptide-MHC overcomes galectin-TCR interactions to induce clustering, F-actin transfer to the immune synapse and signaling. Concurrently, galectin targets CD45 to the immune synapse, suppressing Lck activation and TCR signaling. Differential partitioning of TCR/CD4-Lck versus CD45 in the early immune synapse is in part predetermined by galectin-glycoprotein lattice control of GEM structure prior to encounter with TCR ligand.

Link to Immunological Reviews Article


Pin It on Pinterest

Come Share With Us!

Share this post and help us spread the word.