Journal of Immunological Reviews – Figure 5
Figure. 5 – Metabolism controls cell growth by regulating the galectin-glycoprotein lattice.
The nutrient environment and/or growth signaling by TCR influences UDP-GlcNAc production by the hexosamine pathway, which in turn regulates N-glycan branching in the Golgi to control galectin-glycoprotein lattice strength. Subsequent changes in cell surface receptor membrane localization and concentration results in differential responses to external factors (eg. Growth factors, peptide-MHC) that signal to the nucleus.