Journal of Immunological Reviews – Figure 2 Figure. 2 – Regulation of basal TCR signaling by the galectin-glycoprotein lattice. Galectin binding to N-glycans attached to the TCR complex (which is depicted as a single ribbon) inhibits basal signaling via Lck by...
Journal of Immunological Reviews – Figure 5 Figure. 5 – Metabolism controls cell growth by regulating the galectin-glycoprotein lattice. The nutrient environment and/or growth signaling by TCR influences UDP-GlcNAc production by the hexosamine pathway, which in...
Journal of Immunological Reviews – Figure 3 Figure. 3 – Regulation of T cell activation thresholds by the galectin-glycoprotein lattice Galectin binding to N-glycans attached to the TCR complex (which is depicted as a single ribbon) restricts clustering of TCR...
Journal of Immunological Reviews – Cover Publication Summary: Basal, activation, and arrest signaling in T cells determines survival, coordinates responses to pathogens, and, when dysregulated, leads to loss of self-tolerance and autoimmunity. At the T-cell...
